IID

Q15617_Q8N148.1 contacts (residues)

Receptor	R: Secondary Structure	R: Residue	R; Chain	R: Residue number	Ligand	L: Secondary Structure	L: Residue	L: Chain	L: Residue Number
R	H	LEU	A	21	L	H	PHE	V	164
R	H	GLN	A	233	L	H	LEU	V	25
R	H	PHE	A	236	L	H	LEU	V	25
R	H	PHE	A	236	L	H	LEU	V	29
R	H	SER	A	237	L	H	LEU	V	25
R	H	LEU	A	24	L	-	SER	V	8
R	H	GLY	A	240	L	H	PHE	V	28
R	H	SER	A	241	L	H	PHE	V	28
R	H	LEU	A	243	L	H	LEU	V	32
R	H	THR	A	244	L	H	PHE	V	28
R	H	THR	A	244	L	H	VAL	V	83
R	H	PHE	A	247	L	H	LEU	V	32
R	H	PHE	A	247	L	H	VAL	V	36
R	H	ILE	A	248	L	H	PRO	V	79
R	H	LEU	A	25	L	H	PRO	V	95
R	-	ARG	A	259	L	H	TRP	V	50
R	-	HIS	A	264	L	H	PHE	V	68
R	H	VAL	A	268	L	H	PHE	V	103
R	H	GLY	A	27	L	-	THR	V	10
R	H	VAL	A	271	L	H	PHE	V	103
R	H	VAL	A	271	L	H	THR	V	99
R	H	VAL	A	275	L	H	GLU	V	96
R	H	LEU	A	279	L	H	LYS	V	80
R	H	LEU	A	279	L	H	GLU	V	96
R	H	PRO	A	28	L	-	THR	V	10
R	H	PRO	A	28	L	S	SER	V	93
R	H	PRO	A	28	L	H	TYR	V	94
R	H	PRO	A	28	L	H	PRO	V	95
R	H	PHE	A	282	L	S	ILE	V	91
R	H	LEU	A	283	L	H	LYS	V	80
R	H	LEU	A	283	L	H	VAL	V	83
R	H	PHE	A	286	L	H	VAL	V	86
R	H	PHE	A	286	L	-	THR	V	87
R	H	ILE	A	287	L	H	VAL	V	83
R	H	ILE	A	287	L	H	VAL	V	86
R	H	ILE	A	287	L	-	THR	V	87
R	H	PHE	A	29	L	H	PRO	V	95
R	H	PHE	A	290	L	-	GLU	V	88
R	-	CYS	A	291	L	H	VAL	V	86
R	-	CYS	A	291	L	-	THR	V	87
R	H	LYS	A	296	L	-	GLU	V	88
R	H	LEU	A	32	L	S	SER	V	93
R	H	LEU	A	32	L	H	GLU	V	96

- Title of columns started by 'R:' means Receptor, 'L:' means Ligand
- In the Secondary Structure columns: 'H' means that residues in that row are part of Alpha Helix; 'S' - Beta Sheet

Q15617_Q8N148.1 contacts (residues & atoms)

Receptor	R: Secondary Structure	R: Atom	R: Residue	R; Chain	R: Residue number	Ligand	L: Secondary Structure	L; Atom	L: Residue	L: Chain	L: Residue Number
R	H	CD2	LEU	A	21	L	H	CG	PHE	V	164
R	H	CD2	LEU	A	21	L	H	CD2	PHE	V	164
R	H	CD2	LEU	A	21	L	H	HB3	PHE	V	164
R	H	CD2	LEU	A	24	L	-	HB3	SER	V	8
R	H	CD2	LEU	A	24	L	-	HG	SER	V	8
R	H	CA	LEU	A	25	L	H	HG3	PRO	V	95
R	H	CB	LEU	A	25	L	H	HG2	PRO	V	95
R	H	CB	LEU	A	25	L	H	HG3	PRO	V	95
R	H	CG	LEU	A	25	L	H	HG3	PRO	V	95
R	H	CD2	LEU	A	25	L	H	CB	PRO	V	95
R	H	CD2	LEU	A	25	L	H	CG	PRO	V	95
R	H	CD2	LEU	A	25	L	H	HB3	PRO	V	95
R	H	CD2	LEU	A	25	L	H	HG2	PRO	V	95
R	H	CD2	LEU	A	25	L	H	HG3	PRO	V	95
R	H	CA	GLY	A	27	L	-	HG21	THR	V	10
R	H	CA	GLY	A	27	L	-	HG23	THR	V	10
R	H	C	GLY	A	27	L	-	HB	THR	V	10
R	H	C	GLY	A	27	L	-	HG21	THR	V	10
R	H	C	GLY	A	27	L	-	HG23	THR	V	10
R	H	O	GLY	A	27	L	-	HB	THR	V	10
R	H	O	GLY	A	27	L	-	HG21	THR	V	10
R	H	N	PRO	A	28	L	-	CB	THR	V	10
R	H	N	PRO	A	28	L	-	CG2	THR	V	10
R	H	N	PRO	A	28	L	-	HB	THR	V	10
R	H	N	PRO	A	28	L	-	HG21	THR	V	10
R	H	N	PRO	A	28	L	-	HG23	THR	V	10
R	H	CA	PRO	A	28	L	-	CB	THR	V	10
R	H	CA	PRO	A	28	L	-	O	THR	V	10
R	H	CA	PRO	A	28	L	-	HB	THR	V	10
R	H	CA	PRO	A	28	L	S	HB2	SER	V	93
R	H	C	PRO	A	28	L	S	HB2	SER	V	93
R	H	CB	PRO	A	28	L	-	O	THR	V	10
R	H	CB	PRO	A	28	L	-	HA	THR	V	10
R	H	CB	PRO	A	28	L	-	HB	THR	V	10
R	H	CB	PRO	A	28	L	S	CB	SER	V	93
R	H	CB	PRO	A	28	L	S	HB2	SER	V	93
R	H	CB	PRO	A	28	L	H	H	TYR	V	94
R	H	CB	PRO	A	28	L	H	HB3	TYR	V	94
R	H	CB	PRO	A	28	L	H	CD	PRO	V	95
R	H	CB	PRO	A	28	L	H	HG2	PRO	V	95
R	H	CB	PRO	A	28	L	H	HD2	PRO	V	95
R	H	CB	PRO	A	28	L	H	HD3	PRO	V	95
R	H	O	PRO	A	28	L	S	HB2	SER	V	93
R	H	O	PRO	A	28	L	S	HB3	SER	V	93
R	H	CG	PRO	A	28	L	-	CA	THR	V	10
R	H	CG	PRO	A	28	L	-	C	THR	V	10
R	H	CG	PRO	A	28	L	-	CB	THR	V	10
R	H	CG	PRO	A	28	L	-	O	THR	V	10
R	H	CG	PRO	A	28	L	-	CG2	THR	V	10
R	H	CG	PRO	A	28	L	-	HA	THR	V	10
R	H	CG	PRO	A	28	L	-	HB	THR	V	10
R	H	CG	PRO	A	28	L	-	HG23	THR	V	10
R	H	CG	PRO	A	28	L	H	H	TYR	V	94
R	H	CG	PRO	A	28	L	H	HB3	TYR	V	94
R	H	CG	PRO	A	28	L	H	CD	PRO	V	95
R	H	CG	PRO	A	28	L	H	HD2	PRO	V	95
R	H	CD	PRO	A	28	L	-	CB	THR	V	10
R	H	CD	PRO	A	28	L	-	CG2	THR	V	10
R	H	CD	PRO	A	28	L	-	HA	THR	V	10
R	H	CD	PRO	A	28	L	-	HB	THR	V	10
R	H	CD	PRO	A	28	L	-	HG21	THR	V	10
R	H	CD	PRO	A	28	L	-	HG23	THR	V	10
R	H	CD1	PHE	A	29	L	H	HG2	PRO	V	95
R	H	CD2	PHE	A	29	L	H	HG2	PRO	V	95
R	H	CE1	PHE	A	29	L	H	HB2	PRO	V	95
R	H	CE1	PHE	A	29	L	H	HG2	PRO	V	95
R	H	CE2	PHE	A	29	L	H	HG2	PRO	V	95
R	H	CZ	PHE	A	29	L	H	CB	PRO	V	95
R	H	CZ	PHE	A	29	L	H	HB2	PRO	V	95
R	H	CZ	PHE	A	29	L	H	HB3	PRO	V	95
R	H	CZ	PHE	A	29	L	H	HG2	PRO	V	95
R	H	CG	LEU	A	32	L	S	CB	SER	V	93
R	H	CG	LEU	A	32	L	S	HB3	SER	V	93
R	H	CD1	LEU	A	32	L	S	CB	SER	V	93
R	H	CD1	LEU	A	32	L	S	OG	SER	V	93
R	H	CD1	LEU	A	32	L	S	HB2	SER	V	93
R	H	CD1	LEU	A	32	L	S	HB3	SER	V	93
R	H	CD1	LEU	A	32	L	S	HG	SER	V	93
R	H	CD1	LEU	A	32	L	H	CD	GLU	V	96
R	H	CD1	LEU	A	32	L	H	OE1	GLU	V	96
R	H	CD1	LEU	A	32	L	H	OE2	GLU	V	96
R	H	CD2	LEU	A	32	L	S	HB3	SER	V	93
R	H	CA	GLN	A	233	L	H	HD23	LEU	V	25
R	H	C	GLN	A	233	L	H	HD23	LEU	V	25
R	H	CB	GLN	A	233	L	H	HD21	LEU	V	25
R	H	CB	GLN	A	233	L	H	HD23	LEU	V	25
R	H	O	GLN	A	233	L	H	CD2	LEU	V	25
R	H	O	GLN	A	233	L	H	HD21	LEU	V	25
R	H	O	GLN	A	233	L	H	HD22	LEU	V	25
R	H	O	GLN	A	233	L	H	HD23	LEU	V	25
R	H	CG	GLN	A	233	L	H	CD2	LEU	V	25
R	H	CG	GLN	A	233	L	H	HD21	LEU	V	25
R	H	CG	GLN	A	233	L	H	HD22	LEU	V	25
R	H	CG	GLN	A	233	L	H	HD23	LEU	V	25
R	H	CD	GLN	A	233	L	H	HD21	LEU	V	25
R	H	NE2	GLN	A	233	L	H	HD21	LEU	V	25
R	H	CA	PHE	A	236	L	H	HD12	LEU	V	25
R	H	CA	PHE	A	236	L	H	HD12	LEU	V	29
R	H	CA	PHE	A	236	L	H	HD22	LEU	V	29
R	H	C	PHE	A	236	L	H	CD1	LEU	V	25
R	H	C	PHE	A	236	L	H	HD12	LEU	V	25
R	H	C	PHE	A	236	L	H	HD13	LEU	V	25
R	H	C	PHE	A	236	L	H	HD22	LEU	V	29
R	H	CB	PHE	A	236	L	H	HD12	LEU	V	25
R	H	CB	PHE	A	236	L	H	HD23	LEU	V	25
R	H	CB	PHE	A	236	L	H	CD1	LEU	V	29
R	H	CB	PHE	A	236	L	H	CD2	LEU	V	29
R	H	CB	PHE	A	236	L	H	HD12	LEU	V	29
R	H	CB	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CB	PHE	A	236	L	H	HD22	LEU	V	29
R	H	O	PHE	A	236	L	H	HD12	LEU	V	25
R	H	O	PHE	A	236	L	H	HD22	LEU	V	29
R	H	CG	PHE	A	236	L	H	CD1	LEU	V	29
R	H	CG	PHE	A	236	L	H	CD2	LEU	V	29
R	H	CG	PHE	A	236	L	H	HD12	LEU	V	29
R	H	CG	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CG	PHE	A	236	L	H	HD22	LEU	V	29
R	H	CG	PHE	A	236	L	H	HD23	LEU	V	29
R	H	CD1	PHE	A	236	L	H	CG	LEU	V	29
R	H	CD1	PHE	A	236	L	H	CD1	LEU	V	29
R	H	CD1	PHE	A	236	L	H	CD2	LEU	V	29
R	H	CD1	PHE	A	236	L	H	HD12	LEU	V	29
R	H	CD1	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CD1	PHE	A	236	L	H	HD22	LEU	V	29
R	H	CD1	PHE	A	236	L	H	HD23	LEU	V	29
R	H	CD2	PHE	A	236	L	H	HD12	LEU	V	29
R	H	CD2	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CE1	PHE	A	236	L	H	CD2	LEU	V	29
R	H	CE1	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CE1	PHE	A	236	L	H	HD22	LEU	V	29
R	H	CE1	PHE	A	236	L	H	HD23	LEU	V	29
R	H	CE2	PHE	A	236	L	H	HD13	LEU	V	29
R	H	CZ	PHE	A	236	L	H	HD13	LEU	V	29
R	H	N	SER	A	237	L	H	CD1	LEU	V	25
R	H	N	SER	A	237	L	H	HD12	LEU	V	25
R	H	N	SER	A	237	L	H	HD13	LEU	V	25
R	H	N	SER	A	237	L	H	HD22	LEU	V	25
R	H	N	SER	A	237	L	H	HD23	LEU	V	25
R	H	CA	SER	A	237	L	H	CD1	LEU	V	25
R	H	CA	SER	A	237	L	H	HD12	LEU	V	25
R	H	CA	SER	A	237	L	H	HD13	LEU	V	25
R	H	CA	SER	A	237	L	H	HD22	LEU	V	25
R	H	CB	SER	A	237	L	H	HD13	LEU	V	25
R	H	CB	SER	A	237	L	H	HD22	LEU	V	25
R	H	OG	SER	A	237	L	H	HD13	LEU	V	25
R	H	OG	SER	A	237	L	H	HD22	LEU	V	25
R	H	N	GLY	A	240	L	H	HE1	PHE	V	28
R	H	CA	GLY	A	240	L	H	CE1	PHE	V	28
R	H	CA	GLY	A	240	L	H	CZ	PHE	V	28
R	H	CA	GLY	A	240	L	H	HE1	PHE	V	28
R	H	CA	GLY	A	240	L	H	HZ	PHE	V	28
R	H	C	GLY	A	240	L	H	CE1	PHE	V	28
R	H	C	GLY	A	240	L	H	CZ	PHE	V	28
R	H	C	GLY	A	240	L	H	HE1	PHE	V	28
R	H	C	GLY	A	240	L	H	HZ	PHE	V	28
R	H	O	GLY	A	240	L	H	CE1	PHE	V	28
R	H	O	GLY	A	240	L	H	CZ	PHE	V	28
R	H	O	GLY	A	240	L	H	HE1	PHE	V	28
R	H	O	GLY	A	240	L	H	HZ	PHE	V	28
R	H	N	SER	A	241	L	H	HZ	PHE	V	28
R	H	CB	LEU	A	243	L	H	HD22	LEU	V	32
R	H	CD1	LEU	A	243	L	H	HD22	LEU	V	32
R	H	N	THR	A	244	L	H	HZ	PHE	V	28
R	H	CB	THR	A	244	L	H	HE2	PHE	V	28
R	H	CB	THR	A	244	L	H	HZ	PHE	V	28
R	H	CG2	THR	A	244	L	H	HE2	PHE	V	28
R	H	CG2	THR	A	244	L	H	HG22	VAL	V	83
R	H	OG1	THR	A	244	L	H	CE2	PHE	V	28
R	H	OG1	THR	A	244	L	H	CZ	PHE	V	28
R	H	OG1	THR	A	244	L	H	HE2	PHE	V	28
R	H	OG1	THR	A	244	L	H	HZ	PHE	V	28
R	H	CD2	PHE	A	247	L	H	HD13	LEU	V	32
R	H	CE1	PHE	A	247	L	H	HG23	VAL	V	36
R	H	CE2	PHE	A	247	L	H	HD13	LEU	V	32
R	H	CE2	PHE	A	247	L	H	HG22	VAL	V	36
R	H	CE2	PHE	A	247	L	H	HG23	VAL	V	36
R	H	CZ	PHE	A	247	L	H	CG2	VAL	V	36
R	H	CZ	PHE	A	247	L	H	HG22	VAL	V	36
R	H	CZ	PHE	A	247	L	H	HG23	VAL	V	36
R	H	CG1	ILE	A	248	L	H	HB2	PRO	V	79
R	H	CD1	ILE	A	248	L	H	HB2	PRO	V	79
R	-	NH2	ARG	A	259	L	H	CZ3	TRP	V	50
R	-	NH2	ARG	A	259	L	H	HZ3	TRP	V	50
R	-	ND1	HIS	A	264	L	H	HZ	PHE	V	68
R	-	CE1	HIS	A	264	L	H	HE2	PHE	V	68
R	-	CE1	HIS	A	264	L	H	HZ	PHE	V	68
R	H	CG2	VAL	A	268	L	H	HE1	PHE	V	103
R	H	CG2	VAL	A	268	L	H	HZ	PHE	V	103
R	H	CB	VAL	A	271	L	H	HG21	THR	V	99
R	H	CB	VAL	A	271	L	H	HE2	PHE	V	103
R	H	CG1	VAL	A	271	L	H	CG2	THR	V	99
R	H	CG1	VAL	A	271	L	H	HG21	THR	V	99
R	H	CG1	VAL	A	271	L	H	HG22	THR	V	99
R	H	CG1	VAL	A	271	L	H	HG23	THR	V	99
R	H	CG1	VAL	A	271	L	H	HE2	PHE	V	103
R	H	CG2	VAL	A	271	L	H	HE2	PHE	V	103
R	H	CG2	VAL	A	275	L	H	HG2	GLU	V	96
R	H	N	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CA	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CB	LEU	A	279	L	H	CD	GLU	V	96
R	H	CB	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CG	LEU	A	279	L	H	CD	GLU	V	96
R	H	CG	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CG	LEU	A	279	L	H	OE2	GLU	V	96
R	H	CD1	LEU	A	279	L	H	HZ1	LYS	V	80
R	H	CD1	LEU	A	279	L	H	HZ3	LYS	V	80
R	H	CD1	LEU	A	279	L	H	CD	GLU	V	96
R	H	CD1	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CD1	LEU	A	279	L	H	OE2	GLU	V	96
R	H	CD2	LEU	A	279	L	H	CD	GLU	V	96
R	H	CD2	LEU	A	279	L	H	OE1	GLU	V	96
R	H	CD2	LEU	A	279	L	H	OE2	GLU	V	96
R	H	CD2	LEU	A	279	L	H	HB3	GLU	V	96
R	H	CD2	LEU	A	279	L	H	HG2	GLU	V	96
R	H	CE1	PHE	A	282	L	S	CB	ILE	V	91
R	H	CE1	PHE	A	282	L	S	O	ILE	V	91
R	H	CE1	PHE	A	282	L	S	HB	ILE	V	91
R	H	CE2	PHE	A	282	L	S	HB	ILE	V	91
R	H	CE2	PHE	A	282	L	S	HD13	ILE	V	91
R	H	CZ	PHE	A	282	L	S	CB	ILE	V	91
R	H	CZ	PHE	A	282	L	S	HB	ILE	V	91
R	H	CZ	PHE	A	282	L	S	HG21	ILE	V	91
R	H	CZ	PHE	A	282	L	S	HG23	ILE	V	91
R	H	CZ	PHE	A	282	L	S	HD13	ILE	V	91
R	H	CG	LEU	A	283	L	H	HZ3	LYS	V	80
R	H	CG	LEU	A	283	L	H	HG12	VAL	V	83
R	H	CG	LEU	A	283	L	H	HG23	VAL	V	83
R	H	CD1	LEU	A	283	L	H	HZ3	LYS	V	80
R	H	CD1	LEU	A	283	L	H	CG2	VAL	V	83
R	H	CD1	LEU	A	283	L	H	HG12	VAL	V	83
R	H	CD1	LEU	A	283	L	H	HG23	VAL	V	83
R	H	CD2	LEU	A	283	L	H	NZ	LYS	V	80
R	H	CD2	LEU	A	283	L	H	HZ1	LYS	V	80
R	H	CD2	LEU	A	283	L	H	HZ2	LYS	V	80
R	H	CD2	LEU	A	283	L	H	HZ3	LYS	V	80
R	H	CD2	LEU	A	283	L	H	CG1	VAL	V	83
R	H	CD2	LEU	A	283	L	H	HG11	VAL	V	83
R	H	CD2	LEU	A	283	L	H	HG12	VAL	V	83
R	H	CD2	LEU	A	283	L	H	HG13	VAL	V	83
R	H	CD2	LEU	A	283	L	H	HG23	VAL	V	83
R	H	CA	PHE	A	286	L	-	CG2	THR	V	87
R	H	CA	PHE	A	286	L	-	HG22	THR	V	87
R	H	C	PHE	A	286	L	-	CG2	THR	V	87
R	H	C	PHE	A	286	L	-	HG22	THR	V	87
R	H	CB	PHE	A	286	L	-	CB	THR	V	87
R	H	CB	PHE	A	286	L	-	CG2	THR	V	87
R	H	CB	PHE	A	286	L	-	HB	THR	V	87
R	H	CB	PHE	A	286	L	-	HG21	THR	V	87
R	H	CB	PHE	A	286	L	-	HG22	THR	V	87
R	H	CB	PHE	A	286	L	-	HG23	THR	V	87
R	H	O	PHE	A	286	L	H	O	VAL	V	86
R	H	O	PHE	A	286	L	-	HA	THR	V	87
R	H	O	PHE	A	286	L	-	HG22	THR	V	87
R	H	CG	PHE	A	286	L	-	HB	THR	V	87
R	H	CG	PHE	A	286	L	-	HG21	THR	V	87
R	H	CG	PHE	A	286	L	-	HG22	THR	V	87
R	H	CD1	PHE	A	286	L	-	HB	THR	V	87
R	H	N	ILE	A	287	L	-	HG22	THR	V	87
R	H	CA	ILE	A	287	L	H	HG21	VAL	V	86
R	H	CG1	ILE	A	287	L	H	HG13	VAL	V	83
R	H	CG1	ILE	A	287	L	H	HG22	VAL	V	83
R	H	CG1	ILE	A	287	L	H	HG21	VAL	V	86
R	H	CG1	ILE	A	287	L	H	HG22	VAL	V	86
R	H	CG2	ILE	A	287	L	H	HG22	VAL	V	86
R	H	CD1	ILE	A	287	L	H	HG13	VAL	V	83
R	H	CD1	ILE	A	287	L	H	HG22	VAL	V	83
R	H	CB	PHE	A	290	L	-	HG2	GLU	V	88
R	H	O	PHE	A	290	L	-	HG2	GLU	V	88
R	-	N	CYS	A	291	L	H	O	VAL	V	86
R	-	CA	CYS	A	291	L	H	O	VAL	V	86
R	-	CB	CYS	A	291	L	H	CB	VAL	V	86
R	-	CB	CYS	A	291	L	H	O	VAL	V	86
R	-	CB	CYS	A	291	L	H	HA	VAL	V	86
R	-	CB	CYS	A	291	L	H	HB	VAL	V	86
R	-	SG	CYS	A	291	L	H	CA	VAL	V	86
R	-	SG	CYS	A	291	L	H	C	VAL	V	86
R	-	SG	CYS	A	291	L	H	CB	VAL	V	86
R	-	SG	CYS	A	291	L	H	O	VAL	V	86
R	-	SG	CYS	A	291	L	H	CG1	VAL	V	86
R	-	SG	CYS	A	291	L	H	CG2	VAL	V	86
R	-	SG	CYS	A	291	L	H	HA	VAL	V	86
R	-	SG	CYS	A	291	L	H	HB	VAL	V	86
R	-	SG	CYS	A	291	L	H	HG11	VAL	V	86
R	-	SG	CYS	A	291	L	H	HG21	VAL	V	86
R	-	SG	CYS	A	291	L	H	HG22	VAL	V	86
R	-	SG	CYS	A	291	L	-	N	THR	V	87
R	-	SG	CYS	A	291	L	-	HA	THR	V	87
R	H	CE	LYS	A	296	L	-	OE1	GLU	V	88

- Title of columns started by 'R:' means Receptor, 'L:' means Ligand
- In the Secondary Structure columns: 'H' means that residues/atoms in that row are part of Alpha Helix; 'S' - Beta Sheet

Krembil, Jurisica Lab. July 16, 2025 Database: 1.0.4.1