IID

Q8NGF0_Q9H2C5.1 contacts (residues)

Receptor	R: Secondary Structure	R: Residue	R; Chain	R: Residue number	Ligand	L: Secondary Structure	L: Residue	L: Chain	L: Residue Number
R	H	ILE	A	230	L	H	LEU	V	256
R	H	ILE	A	230	L	H	PHE	V	260
R	H	MET	A	231	L	H	LEU	V	252
R	H	THR	A	234	L	H	LEU	V	256
R	H	ILE	A	238	L	H	ILE	V	214
R	H	LEU	A	241	L	H	PHE	V	263
R	H	GLN	A	242	L	H	ILE	V	215
R	H	PHE	A	245	L	H	PHE	V	207
R	H	LEU	A	257	L	H	PHE	V	267
R	H	GLY	A	261	L	H	PHE	V	267
R	H	ILE	A	264	L	H	PHE	V	263
R	H	ILE	A	264	L	H	PHE	V	267
R	H	CYS	A	265	L	H	PHE	V	267
R	H	CYS	A	265	L	-	GLY	V	268
R	H	CYS	A	265	L	-	SER	V	269
R	H	CYS	A	265	L	-	HIS	V	270
R	H	CYS	A	265	L	-	ILE	V	271
R	H	LEU	A	268	L	H	PHE	V	260
R	H	LEU	A	268	L	H	PHE	V	263
R	H	LEU	A	268	L	H	THR	V	264
R	H	LEU	A	268	L	H	PHE	V	267
R	H	LEU	A	268	L	-	ILE	V	271
R	H	LEU	A	269	L	-	HIS	V	270
R	H	LEU	A	269	L	-	ILE	V	271
R	H	TYR	A	271	L	H	PHE	V	260
R	H	VAL	A	272	L	H	PHE	V	260
R	H	VAL	A	272	L	H	THR	V	264
R	H	VAL	A	272	L	H	ILE	V	275
R	H	VAL	A	272	L	H	LEU	V	279
R	H	PRO	A	273	L	H	ILE	V	275
R	H	LEU	A	275	L	H	PHE	V	260
R	H	PHE	A	276	L	H	LEU	V	278
R	H	PHE	A	276	L	H	LEU	V	282
R	H	PHE	A	279	L	H	LEU	V	257
R	H	PHE	A	283	L	H	PHE	V	289
R	H	PHE	A	283	L	H	LEU	V	290
R	H	PHE	A	283	L	H	PRO	V	32
R	-	GLY	A	284	L	H	PRO	V	32
R	-	ARG	A	286	L	H	TRP	V	28
R	-	ARG	A	286	L	H	PRO	V	32
R	-	SER	A	287	L	H	TRP	V	28
R	-	SER	A	287	L	H	ILE	V	29
R	-	SER	A	287	L	H	ILE	V	31
R	-	SER	A	287	L	H	PRO	V	32
R	-	VAL	A	288	L	H	PRO	V	32
R	-	PRO	A	289	L	H	TRP	V	28
R	H	TYR	A	291	L	-	VAL	V	25
R	H	LEU	A	296	L	H	TYR	V	274
R	H	LEU	A	307	L	-	HIS	V	270
R	H	VAL	A	310	L	-	HIS	V	270
R	H	ILE	A	311	L	-	HIS	V	270

- Title of columns started by 'R:' means Receptor, 'L:' means Ligand
- In the Secondary Structure columns: 'H' means that residues in that row are part of Alpha Helix; 'S' - Beta Sheet

Q8NGF0_Q9H2C5.1 contacts (residues & atoms)

Receptor	R: Secondary Structure	R: Atom	R: Residue	R; Chain	R: Residue number	Ligand	L: Secondary Structure	L; Atom	L: Residue	L: Chain	L: Residue Number
R	H	CG1	ILE	A	230	L	H	HZ	PHE	V	260
R	H	CG2	ILE	A	230	L	H	HD22	LEU	V	256
R	H	CG2	ILE	A	230	L	H	HD23	LEU	V	256
R	H	CG2	ILE	A	230	L	H	CZ	PHE	V	260
R	H	CG2	ILE	A	230	L	H	HE2	PHE	V	260
R	H	CG2	ILE	A	230	L	H	HZ	PHE	V	260
R	H	CD1	ILE	A	230	L	H	HZ	PHE	V	260
R	H	SD	MET	A	231	L	H	HD12	LEU	V	252
R	H	SD	MET	A	231	L	H	HD22	LEU	V	252
R	H	CE	MET	A	231	L	H	CD2	LEU	V	252
R	H	CE	MET	A	231	L	H	HD12	LEU	V	252
R	H	CE	MET	A	231	L	H	HD13	LEU	V	252
R	H	CE	MET	A	231	L	H	HD22	LEU	V	252
R	H	CE	MET	A	231	L	H	HD23	LEU	V	252
R	H	OG1	THR	A	234	L	H	HD21	LEU	V	256
R	H	CD1	ILE	A	238	L	H	HD12	ILE	V	214
R	H	CG	LEU	A	241	L	H	HZ	PHE	V	263
R	H	CD1	LEU	A	241	L	H	CZ	PHE	V	263
R	H	CD1	LEU	A	241	L	H	HZ	PHE	V	263
R	H	NE2	GLN	A	242	L	H	CD1	ILE	V	215
R	H	NE2	GLN	A	242	L	H	HG13	ILE	V	215
R	H	NE2	GLN	A	242	L	H	HD11	ILE	V	215
R	H	NE2	GLN	A	242	L	H	HD12	ILE	V	215
R	H	CE2	PHE	A	245	L	H	HZ	PHE	V	207
R	H	O	LEU	A	257	L	H	HE1	PHE	V	267
R	H	CA	GLY	A	261	L	H	CD1	PHE	V	267
R	H	CA	GLY	A	261	L	H	CE1	PHE	V	267
R	H	CA	GLY	A	261	L	H	HD1	PHE	V	267
R	H	CA	GLY	A	261	L	H	HE1	PHE	V	267
R	H	C	GLY	A	261	L	H	HB3	PHE	V	267
R	H	C	GLY	A	261	L	H	HD1	PHE	V	267
R	H	O	GLY	A	261	L	H	HB3	PHE	V	267
R	H	O	GLY	A	261	L	H	HD1	PHE	V	267
R	H	CB	ILE	A	264	L	H	HD1	PHE	V	263
R	H	CB	ILE	A	264	L	H	HE1	PHE	V	263
R	H	CB	ILE	A	264	L	H	HB3	PHE	V	267
R	H	CG1	ILE	A	264	L	H	CE1	PHE	V	263
R	H	CG1	ILE	A	264	L	H	HD1	PHE	V	263
R	H	CG1	ILE	A	264	L	H	HE1	PHE	V	263
R	H	CG2	ILE	A	264	L	H	CD1	PHE	V	263
R	H	CG2	ILE	A	264	L	H	CE1	PHE	V	263
R	H	CG2	ILE	A	264	L	H	HB2	PHE	V	263
R	H	CG2	ILE	A	264	L	H	HD1	PHE	V	263
R	H	CG2	ILE	A	264	L	H	HE1	PHE	V	263
R	H	CG2	ILE	A	264	L	H	CB	PHE	V	267
R	H	CG2	ILE	A	264	L	H	CG	PHE	V	267
R	H	CG2	ILE	A	264	L	H	CD2	PHE	V	267
R	H	CG2	ILE	A	264	L	H	HB2	PHE	V	267
R	H	CG2	ILE	A	264	L	H	HB3	PHE	V	267
R	H	CG2	ILE	A	264	L	H	HD2	PHE	V	267
R	H	CD1	ILE	A	264	L	H	CD1	PHE	V	263
R	H	CD1	ILE	A	264	L	H	CE1	PHE	V	263
R	H	CD1	ILE	A	264	L	H	HD1	PHE	V	263
R	H	CD1	ILE	A	264	L	H	HE1	PHE	V	263
R	H	CD1	ILE	A	264	L	H	CE2	PHE	V	267
R	H	N	CYS	A	265	L	H	HB3	PHE	V	267
R	H	CA	CYS	A	265	L	H	O	PHE	V	267
R	H	CA	CYS	A	265	L	H	HB3	PHE	V	267
R	H	CB	CYS	A	265	L	H	O	PHE	V	267
R	H	CB	CYS	A	265	L	H	HB3	PHE	V	267
R	H	O	CYS	A	265	L	-	HD11	ILE	V	271
R	H	SG	CYS	A	265	L	H	O	PHE	V	267
R	H	SG	CYS	A	265	L	-	HA3	GLY	V	268
R	H	SG	CYS	A	265	L	-	HG	SER	V	269
R	H	SG	CYS	A	265	L	-	ND1	HIS	V	270
R	H	SG	CYS	A	265	L	-	H	HIS	V	270
R	H	SG	CYS	A	265	L	-	HB2	HIS	V	270
R	H	CA	LEU	A	268	L	-	HD11	ILE	V	271
R	H	C	LEU	A	268	L	-	HD11	ILE	V	271
R	H	CB	LEU	A	268	L	H	CG2	THR	V	264
R	H	CB	LEU	A	268	L	H	HG22	THR	V	264
R	H	CB	LEU	A	268	L	H	HG23	THR	V	264
R	H	CB	LEU	A	268	L	-	CD1	ILE	V	271
R	H	CB	LEU	A	268	L	-	HD11	ILE	V	271
R	H	CB	LEU	A	268	L	-	HD12	ILE	V	271
R	H	CB	LEU	A	268	L	-	HD13	ILE	V	271
R	H	O	LEU	A	268	L	-	HD11	ILE	V	271
R	H	CG	LEU	A	268	L	H	HB2	PHE	V	263
R	H	CG	LEU	A	268	L	H	CG2	THR	V	264
R	H	CG	LEU	A	268	L	H	HA	THR	V	264
R	H	CG	LEU	A	268	L	H	HG22	THR	V	264
R	H	CG	LEU	A	268	L	H	HG23	THR	V	264
R	H	CG	LEU	A	268	L	-	HD11	ILE	V	271
R	H	CD1	LEU	A	268	L	H	CA	PHE	V	263
R	H	CD1	LEU	A	268	L	H	C	PHE	V	263
R	H	CD1	LEU	A	268	L	H	CB	PHE	V	263
R	H	CD1	LEU	A	268	L	H	O	PHE	V	263
R	H	CD1	LEU	A	268	L	H	HB2	PHE	V	263
R	H	CD1	LEU	A	268	L	H	HB3	PHE	V	263
R	H	CD1	LEU	A	268	L	H	N	THR	V	264
R	H	CD1	LEU	A	268	L	H	CA	THR	V	264
R	H	CD1	LEU	A	268	L	H	CG2	THR	V	264
R	H	CD1	LEU	A	268	L	H	H	THR	V	264
R	H	CD1	LEU	A	268	L	H	HA	THR	V	264
R	H	CD1	LEU	A	268	L	H	HG22	THR	V	264
R	H	CD1	LEU	A	268	L	H	HG23	THR	V	264
R	H	CD1	LEU	A	268	L	H	HB2	PHE	V	267
R	H	CD1	LEU	A	268	L	-	HD11	ILE	V	271
R	H	CD1	LEU	A	268	L	-	HD12	ILE	V	271
R	H	CD2	LEU	A	268	L	H	CD1	PHE	V	260
R	H	CD2	LEU	A	268	L	H	HA	PHE	V	260
R	H	CD2	LEU	A	268	L	H	HD1	PHE	V	260
R	H	CD2	LEU	A	268	L	H	HE1	PHE	V	260
R	H	CD2	LEU	A	268	L	H	CB	PHE	V	263
R	H	CD2	LEU	A	268	L	H	HB2	PHE	V	263
R	H	CD2	LEU	A	268	L	H	HB3	PHE	V	263
R	H	CD2	LEU	A	268	L	H	CG2	THR	V	264
R	H	CD2	LEU	A	268	L	H	HG22	THR	V	264
R	H	CD2	LEU	A	268	L	H	HG23	THR	V	264
R	H	N	LEU	A	269	L	-	HD11	ILE	V	271
R	H	CA	LEU	A	269	L	-	HG12	ILE	V	271
R	H	CG	LEU	A	269	L	-	HB2	HIS	V	270
R	H	CG	LEU	A	269	L	-	HG12	ILE	V	271
R	H	CG	LEU	A	269	L	-	HG13	ILE	V	271
R	H	CD1	LEU	A	269	L	-	HB2	HIS	V	270
R	H	CD1	LEU	A	269	L	-	HB3	HIS	V	270
R	H	CD2	LEU	A	269	L	-	O	HIS	V	270
R	H	CD2	LEU	A	269	L	-	HB2	HIS	V	270
R	H	CD2	LEU	A	269	L	-	CG1	ILE	V	271
R	H	CD2	LEU	A	269	L	-	HA	ILE	V	271
R	H	CD2	LEU	A	269	L	-	HG12	ILE	V	271
R	H	CD2	LEU	A	269	L	-	HG13	ILE	V	271
R	H	CB	TYR	A	271	L	H	HE1	PHE	V	260
R	H	CB	TYR	A	271	L	H	HZ	PHE	V	260
R	H	CA	VAL	A	272	L	H	HD13	LEU	V	279
R	H	CB	VAL	A	272	L	H	HG21	THR	V	264
R	H	CB	VAL	A	272	L	H	HG22	ILE	V	275
R	H	CB	VAL	A	272	L	H	CD1	LEU	V	279
R	H	CB	VAL	A	272	L	H	HD13	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HG21	THR	V	264
R	H	CG1	VAL	A	272	L	H	CG2	ILE	V	275
R	H	CG1	VAL	A	272	L	H	HG21	ILE	V	275
R	H	CG1	VAL	A	272	L	H	HG22	ILE	V	275
R	H	CG1	VAL	A	272	L	H	HG23	ILE	V	275
R	H	CG1	VAL	A	272	L	H	CG	LEU	V	279
R	H	CG1	VAL	A	272	L	H	CD1	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HG	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HD11	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HD12	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HD13	LEU	V	279
R	H	CG1	VAL	A	272	L	H	HD22	LEU	V	279
R	H	CG2	VAL	A	272	L	H	HB3	PHE	V	260
R	H	CG2	VAL	A	272	L	H	HD1	PHE	V	260
R	H	CG2	VAL	A	272	L	H	CG2	THR	V	264
R	H	CG2	VAL	A	272	L	H	HG21	THR	V	264
R	H	CG2	VAL	A	272	L	H	HG22	THR	V	264
R	H	CG2	VAL	A	272	L	H	HG23	THR	V	264
R	H	CG2	VAL	A	272	L	H	CD1	LEU	V	279
R	H	CG2	VAL	A	272	L	H	HD12	LEU	V	279
R	H	CG2	VAL	A	272	L	H	HD13	LEU	V	279
R	H	CG	PRO	A	273	L	H	HD12	ILE	V	275
R	H	CD1	LEU	A	275	L	H	CD2	PHE	V	260
R	H	CD1	LEU	A	275	L	H	CE2	PHE	V	260
R	H	CD1	LEU	A	275	L	H	CZ	PHE	V	260
R	H	CD1	LEU	A	275	L	H	HE2	PHE	V	260
R	H	CD1	LEU	A	275	L	H	HZ	PHE	V	260
R	H	CD2	PHE	A	276	L	H	HB3	LEU	V	278
R	H	CD2	PHE	A	276	L	H	HD13	LEU	V	278
R	H	CD2	PHE	A	276	L	H	HD13	LEU	V	282
R	H	CE2	PHE	A	276	L	H	CD1	LEU	V	278
R	H	CE2	PHE	A	276	L	H	HB3	LEU	V	278
R	H	CE2	PHE	A	276	L	H	HD11	LEU	V	278
R	H	CE2	PHE	A	276	L	H	HD13	LEU	V	278
R	H	CE2	PHE	A	276	L	H	HD23	LEU	V	278
R	H	CE2	PHE	A	276	L	H	HD13	LEU	V	282
R	H	CZ	PHE	A	276	L	H	CD1	LEU	V	278
R	H	CZ	PHE	A	276	L	H	HD13	LEU	V	278
R	H	CE2	PHE	A	279	L	H	HD23	LEU	V	257
R	H	O	PHE	A	283	L	H	HB2	PRO	V	32
R	H	O	PHE	A	283	L	H	HB3	PRO	V	32
R	H	CG	PHE	A	283	L	H	HE1	PHE	V	289
R	H	CD1	PHE	A	283	L	H	CE1	PHE	V	289
R	H	CD1	PHE	A	283	L	H	HE1	PHE	V	289
R	H	CD1	PHE	A	283	L	H	HZ	PHE	V	289
R	H	CD1	PHE	A	283	L	H	HD22	LEU	V	290
R	H	CE1	PHE	A	283	L	H	CE1	PHE	V	289
R	H	CE1	PHE	A	283	L	H	HE1	PHE	V	289
R	H	CE1	PHE	A	283	L	H	HZ	PHE	V	289
R	H	CE1	PHE	A	283	L	H	CD2	LEU	V	290
R	H	CE1	PHE	A	283	L	H	HD13	LEU	V	290
R	H	CE1	PHE	A	283	L	H	HD22	LEU	V	290
R	H	CE1	PHE	A	283	L	H	HD23	LEU	V	290
R	H	CE2	PHE	A	283	L	H	HD13	LEU	V	290
R	H	CZ	PHE	A	283	L	H	HE1	PHE	V	289
R	H	CZ	PHE	A	283	L	H	CD2	LEU	V	290
R	H	CZ	PHE	A	283	L	H	HD13	LEU	V	290
R	H	CZ	PHE	A	283	L	H	HD22	LEU	V	290
R	-	CA	GLY	A	284	L	H	HB3	PRO	V	32
R	-	C	GLY	A	284	L	H	HB3	PRO	V	32
R	-	O	GLY	A	284	L	H	CB	PRO	V	32
R	-	O	GLY	A	284	L	H	HB3	PRO	V	32
R	-	O	GLY	A	284	L	H	HG2	PRO	V	32
R	-	C	ARG	A	286	L	H	HD3	PRO	V	32
R	-	O	ARG	A	286	L	H	HE3	TRP	V	28
R	-	N	SER	A	287	L	H	CD	PRO	V	32
R	-	N	SER	A	287	L	H	HB3	PRO	V	32
R	-	N	SER	A	287	L	H	HG2	PRO	V	32
R	-	N	SER	A	287	L	H	HD3	PRO	V	32
R	-	CA	SER	A	287	L	H	O	TRP	V	28
R	-	CA	SER	A	287	L	H	HB	ILE	V	31
R	-	CA	SER	A	287	L	H	N	PRO	V	32
R	-	CA	SER	A	287	L	H	CB	PRO	V	32
R	-	CA	SER	A	287	L	H	CG	PRO	V	32
R	-	CA	SER	A	287	L	H	CD	PRO	V	32
R	-	CA	SER	A	287	L	H	HB3	PRO	V	32
R	-	CA	SER	A	287	L	H	HG2	PRO	V	32
R	-	CA	SER	A	287	L	H	HD2	PRO	V	32
R	-	CA	SER	A	287	L	H	HD3	PRO	V	32
R	-	C	SER	A	287	L	H	O	TRP	V	28
R	-	C	SER	A	287	L	H	HB2	TRP	V	28
R	-	C	SER	A	287	L	H	HA	ILE	V	29
R	-	C	SER	A	287	L	H	CG	PRO	V	32
R	-	C	SER	A	287	L	H	CD	PRO	V	32
R	-	C	SER	A	287	L	H	HG2	PRO	V	32
R	-	C	SER	A	287	L	H	HD2	PRO	V	32
R	-	C	SER	A	287	L	H	HD3	PRO	V	32
R	-	CB	SER	A	287	L	H	O	TRP	V	28
R	-	CB	SER	A	287	L	H	HA	ILE	V	29
R	-	CB	SER	A	287	L	H	C	ILE	V	31
R	-	CB	SER	A	287	L	H	HB	ILE	V	31
R	-	CB	SER	A	287	L	H	N	PRO	V	32
R	-	CB	SER	A	287	L	H	CA	PRO	V	32
R	-	CB	SER	A	287	L	H	CB	PRO	V	32
R	-	CB	SER	A	287	L	H	CG	PRO	V	32
R	-	CB	SER	A	287	L	H	CD	PRO	V	32
R	-	CB	SER	A	287	L	H	HA	PRO	V	32
R	-	CB	SER	A	287	L	H	HB2	PRO	V	32
R	-	CB	SER	A	287	L	H	HB3	PRO	V	32
R	-	CB	SER	A	287	L	H	HG2	PRO	V	32
R	-	CB	SER	A	287	L	H	HG3	PRO	V	32
R	-	CB	SER	A	287	L	H	HD2	PRO	V	32
R	-	CB	SER	A	287	L	H	HD3	PRO	V	32
R	-	O	SER	A	287	L	H	C	TRP	V	28
R	-	O	SER	A	287	L	H	CB	TRP	V	28
R	-	O	SER	A	287	L	H	O	TRP	V	28
R	-	O	SER	A	287	L	H	HB2	TRP	V	28
R	-	O	SER	A	287	L	H	HB3	TRP	V	28
R	-	O	SER	A	287	L	H	N	ILE	V	29
R	-	O	SER	A	287	L	H	HA	ILE	V	29
R	-	O	SER	A	287	L	H	CD	PRO	V	32
R	-	O	SER	A	287	L	H	HG2	PRO	V	32
R	-	O	SER	A	287	L	H	HD2	PRO	V	32
R	-	O	SER	A	287	L	H	HD3	PRO	V	32
R	-	OG	SER	A	287	L	H	C	ILE	V	31
R	-	OG	SER	A	287	L	H	HB	ILE	V	31
R	-	OG	SER	A	287	L	H	HG23	ILE	V	31
R	-	OG	SER	A	287	L	H	N	PRO	V	32
R	-	OG	SER	A	287	L	H	CA	PRO	V	32
R	-	OG	SER	A	287	L	H	C	PRO	V	32
R	-	OG	SER	A	287	L	H	CB	PRO	V	32
R	-	OG	SER	A	287	L	H	CG	PRO	V	32
R	-	OG	SER	A	287	L	H	CD	PRO	V	32
R	-	OG	SER	A	287	L	H	HA	PRO	V	32
R	-	OG	SER	A	287	L	H	HB2	PRO	V	32
R	-	OG	SER	A	287	L	H	HB3	PRO	V	32
R	-	OG	SER	A	287	L	H	HG2	PRO	V	32
R	-	OG	SER	A	287	L	H	HG3	PRO	V	32
R	-	OG	SER	A	287	L	H	HD2	PRO	V	32
R	-	OG	SER	A	287	L	H	HD3	PRO	V	32
R	-	N	VAL	A	288	L	H	HG2	PRO	V	32
R	-	CG2	VAL	A	288	L	H	HG2	PRO	V	32
R	-	CD	PRO	A	289	L	H	HB2	TRP	V	28
R	H	OH	TYR	A	291	L	-	CG1	VAL	V	25
R	H	OH	TYR	A	291	L	-	HG11	VAL	V	25
R	H	OH	TYR	A	291	L	-	HG13	VAL	V	25
R	H	CZ	TYR	A	291	L	-	HG13	VAL	V	25
R	H	CD1	LEU	A	296	L	H	OH	TYR	V	274
R	H	CD1	LEU	A	296	L	H	HE2	TYR	V	274
R	H	CD1	LEU	A	296	L	H	HH	TYR	V	274
R	H	CG	LEU	A	307	L	-	HB3	HIS	V	270
R	H	CD1	LEU	A	307	L	-	CB	HIS	V	270
R	H	CD1	LEU	A	307	L	-	O	HIS	V	270
R	H	CD1	LEU	A	307	L	-	HB2	HIS	V	270
R	H	CD1	LEU	A	307	L	-	HB3	HIS	V	270
R	H	CD2	LEU	A	307	L	-	HB3	HIS	V	270
R	H	CD2	LEU	A	307	L	-	HD2	HIS	V	270
R	H	CG1	VAL	A	310	L	-	HE2	HIS	V	270
R	H	CG1	ILE	A	311	L	-	ND1	HIS	V	270
R	H	CG1	ILE	A	311	L	-	CE1	HIS	V	270
R	H	CG1	ILE	A	311	L	-	HE1	HIS	V	270
R	H	CD1	ILE	A	311	L	-	ND1	HIS	V	270

- Title of columns started by 'R:' means Receptor, 'L:' means Ligand
- In the Secondary Structure columns: 'H' means that residues/atoms in that row are part of Alpha Helix; 'S' - Beta Sheet

Krembil, Jurisica Lab. July 16, 2025 Database: 1.0.4.1