==================================================================================== ((Chimeara commands)) ===================== log clear; // clear the log close session; // close session /bin/chimerax --nogui < ./Vimentin.bat /bin/chimerax --nogui < ./Annexin_A2.bat===================== - dock prep Tools Structure Editing Dock Prep - strip hydrogens Select Chemistry Element H Action Atom/Bonds Delete open /home/rick/mabovsky/InI_Max/va_chimera/Vimentin.pdb; dockprep #1; select H; delete atoms sel; // hydrogen is default delete bonds sel; // hydrogen is default save /home/rick/mabovsky/InI_Max/va_chimera/Vimentin_CMD.pdb relModel #1; ====================== - add hydrogens Tools Structure Editing Add Hydrogens - add charges Tools Stucture Editing Add Charges open /home/rick/mabovsky/InI_Max/va_chimera/Annexin_A2.pdb; addh #1; addcharge #1; save /home/rick/mabovsky/InI_Max/va_chimera/Annexin_A2_CMD.pdb relModel #1; ((InI_Sets)) ==================================================================================== - move to folders where all decoys are. - copy "InI_Sets.jar" there - use one of below to run: (development) java -jar ./InI_Sets.jar . 24 (manually) nohup java -jar ./InI_Sets.jar . 24 > set.out 2>&1 & (srun to computer node) srun --cpus-per-task 1 -o set.out -e set.err java -jar ./InI_Sets.jar . 24 & Input: - '.' is a path to folder 'full' of decoys - 24 is a number of decoys to us Output: Signature_4.txt // 4 is a max distance in 'A' ((Commands)) ========================================================================================= scp ./va_chimera.zip mabovsky@ijcluster.uhnres.utoronto.ca:/home/mabovsky/PP_Docking/MEGADOCK/. unzip va_chimera.zip srun --cpus-per-task 20 --pty bash -i cd /home/mabovsky/PP_Docking/MEGADOCK/va_chimera ../megadock-4.1.1/megadock -R Vimentin_chimera.pdb -L Annexin_A2_chimera.pdb -t 3 -N 10800 ../megadock-4.1.1/decoygen Annexin_A2_chimera.1.pdb Annexin_A2_chimera.pdb Vimentin_chimera-Annexin_A2_chimera.out 1 cat Vimentin_chimera.pdb Annexin_A2_chimera.1.pdb > vim_ann.1.pdb ../megadock-4.1.1/decoygen Annexin_A2_chimera.2.pdb Annexin_A2_chimera.pdb Vimentin_chimera-Annexin_A2_chimera.out 2 cat Vimentin_chimera.pdb Annexin_A2_chimera.2.pdb > vim_ann.2.pdb ../megadock-4.1.1/decoygen Annexin_A2_chimera.3.pdb Annexin_A2_chimera.pdb Vimentin_chimera-Annexin_A2_chimera.out 3 cat Vimentin_chimera.pdb Annexin_A2_chimera.3.pdb > vim_ann.3.pdb ../megadock-4.1.1/decoygen Annexin_A2_chimera.4.pdb Annexin_A2_chimera.pdb Vimentin_chimera-Annexin_A2_chimera.out 4 cat Vimentin_chimera.pdb Annexin_A2_chimera.4.pdb > vim_ann.4.pdb ../megadock-4.1.1/decoygen Annexin_A2_chimera.5.pdb Annexin_A2_chimera.pdb Vimentin_chimera-Annexin_A2_chimera.out 5 cat Vimentin_chimera.pdb Annexin_A2_chimera.5.pdb > vim_ann.5.pdb cd /home/mabovsky/PP_Docking/MEGADOCK/ zip -r va_chimera_done.zip va_chimera cd /home/rick/mabovsky/InI_Max scp mabovsky@ijcluster.uhnres.utoronto.ca:/home/mabovsky/PP_Docking/MEGADOCK/va_chimera_done.zip ./. unzip va_chimera_done.zip <_folders_xx-XX> ==================== scp ./_folders_3_test.zip mabovsky@ijcluster.uhnres.utoronto.ca:/home/mabovsky/PP_Docking/MEGADOCK/run/. unzip _folders_3_test.zip cd _folders_3_test chmod u+x master.sh nohup ./master.sh > master.out 2>&1 & scp ./_folders_i_200.zip mabovsky@ijcluster.uhnres.utoronto.ca:/home/mabovsky/PP_Docking/MEGADOCK/run/. unzip _folders_i_200.zip cd _folders_i_200 chmod u+x master.sh nohup ./master.sh > master.out 2>&1 & ((InI_Delta)) ========================================================================================= cd run # move to run folder # create 2 files here: file = "i.txt" _folders_i_200_done/Signatures_4.0.txt file = "n.txt" _folders_ne_200_done/Signatures_4.0.txt _folders_ne_800_done/Signatures_4.0.txt java -jar InI_Delta.jar # results are: I minus N ------------------------------ CYS-OXT-N-ASN CYS-OXT-N-TRP GLY-OXT-CD2-TYR GLY-OXT-CG-ASN GLY-OXT-N-HIS ILE-OXT-C-TRP ILE-OXT-O-TRP LYS-OXT-OXT-GLU TRP-CD2-OXT-CYS TRP-CG-OXT-CYS >> lstIminusN.size() = 10